Octopus: Optimal Clinical Trials Platform for Multiple Sclerosis

Octopus is a revolutionary trial that will transform the way we test treatments for Progressive Multiple Sclerosis (MS). A smarter way of testing potential treatments, it could deliver life-changing new treatments up to three times faster. 


Octopus is now open to recruitment!

If you are a potential participant or a family member looking for more information about Octopus, visit the For Participants page.
If you're interested in the trial and would like to see if you are eligible, complete the Registration of Interest form.
You can explore which Octopus sites are open at the Octopus Sites page.
To read about Octopus trial news, visit the Publications and media page.
For more information on MS research and practical support for MS, visit the MS Society website.
We apologise that the MRC CTU at UCL Octopus trial team who oversee this website are unable to advise on eligibility and clinical queries.
If you would like to register your interest in Octopus you can contact your MS nurse or complete a Registration of Interest form.

I have MS and I would like to find out more

Click on the images below to find out more about each of these topics
Image of the Octopus logo on a purple background

About Octopus

Find out more about the design of the Octopus trial and who it is for.

Image of a diagram showing different coloured arrows representing arms of Octopus trial. In the middle of the figure there is a vertical line that divides the figure in half.  The left half says 'Analysis Stage 1' and the right half says 'Analysis Stage 2'. Not all the arrows continue past Analysis Stage 1. One arrow only begins half way through Analysis Stage 1.

About MAMS trials

In this section we focus on what a Multi-Arm Multi-Stage (MAMS) trial is, and why it can help research into MS.

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Register Your Interest

I would like to register my interest in Octopus. What do I do next?

From left to right: trial participant Ailsa Guidi, sitting on a wheelchair. Next to her sits her partner Rob Guidi. On the right is trial physician Dr Sean Mangion, smiling. Image courtesy of the MS Society.

Participant Information Sheet

Access the Octopus Participant Information Sheet.


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Frequently Asked Questions (FAQs)

We have put together some of the most frequently asked questions about the trial.

Octopus is funded by the MS Society